About the lab
Bridging fundamental cancer biology with clinical research
Cancer is a dynamic and evolving disease shaped by complex genetic and molecular alterations that influence treatment response and clinical outcomes.
We investigate the biological processes that drive cancer progression and treatment failure while developing innovative strategies to better match patients with the therapies most likely to benefit them.
By bridging fundamental cancer biology with translational and clinical research, we aim to accelerate the development of more personalized, effective, and durable treatment approaches that improve the lives of patients living with cancer.
Research
Major research themes
- Clinical trials to test novel MAPK inhibitor combinations in patients with non-V600 BRAF mutant cancer
- Defining mechanisms of resistance to MAPK inhibitors in cancers with non-V600 BRAF mutations
- Evaluating the role of mutant NRAS in mediating immunotherapy resistance in melanoma
- Characterizing predictors of therapeutic response and resistance in genitourinary cancers
